Michael Sixt's laboratory is studying leukocytes that migrate between different tissues of the body in order to coordinate an immune response. Using advanced microscopy, we are trying to understand how leukocytes, in particular dendritic cells, move and react to guidance cues or change their shape according to different environments.

White blood cells on the move: the series of images shown above are dendritic cells (artificially coloured) caught during migration on two-dimensional surfaces (first row) or three-dimensional environments (second row)